国际病理科学与临床杂志2011，Vol.31Issue(1)：21-24,4.DOI:10.3969/j.issn.1673-2588.2011.01.005
阿托伐他汀联合阿司匹林对不稳定心绞痛患者血清可溶性CD40配体、基质金属蛋白酶-2浓度及心绞痛疗效的影响
Effect of combination of atorvastatin and aspirin on the concentration of serum soluble CD40 ligand,matrix metalloproteinase-2, and angina clinical effect in patients with unstable angina
曹健民1
作者信息
- 1. 南县人民医院心内科,湖南,南县,413200
- 折叠
摘要
Abstract
Objective To observe the effect of combination of atorvastatin· and aspirin on the concentration of serum soluble CD40 ligand (sCD40L) ,matrix metalloproteinase (MMP)-2 and angina clinical effect in patients with unstable angina (UA). Methods Patients with UA were randomly divided into 2 groups: an observation group ( n = 40) and a control group ( n = 40). Patients in the control group were treated with aspirin 100 mg/d based on routine medicine. Patients in the observation group were treated with atorvastatin 10 mg/d based on medicine used in the control group. Both groups were treated for 4 weeks. The concentrations of serum sCD40L and MMP-2 were detected by ELISA before and after treatment and the therapeutical effect was observed. Results The observation group improved more in angina symptoms and decreased in the concentrations of serum sCD40L and MMp-2 than those in the control group (P ＜ 0.05 or P ＜ 0.01 ). Conclusion Combination of atorvastatin and aspirin can improve angina symptoms by decreasing the concentration of sCD40L and MMP-2, restraining inflammatory response and stabilizing coronary atherosclerosis.关键词
阿托伐他汀/阿司匹林/不稳定型心绞痛/sCD40LKey words
atorvastatin/ aspirin/ unstable angina/ sCD40L.引用本文复制引用
曹健民..阿托伐他汀联合阿司匹林对不稳定心绞痛患者血清可溶性CD40配体、基质金属蛋白酶-2浓度及心绞痛疗效的影响 [J].国际病理科学与临床杂志,2011,31(1):21-24,4.
