安徽医科大学学报2011，Vol.46Issue(2)：105-108,4.
肝细胞癌中磷酸化STAT3与上皮型钙粘素的表达及其临床意义
Expression of phosphorylated STAT3 and E-cadherin in hepatocellular carcinoma and their clinical significance
摘要
Abstract
Objective To investigate the expression of activated phosphorylated signal transducer and activator of transcription 3 ( p-STAT3 ) and E-cadherin in hepatocellular carcinoma( HCC), and to analyze their correlations and predictive effects on HCC prognosis. Methods The expression profiles of p-STAT3 and E-cadherin were detected in 100 HCC clinical samples and 10 normal liver tissues by immunohistochemical staining method, and their correlations with clinicopathological parameters were also analyzed. The association between p-STAT3, E-cadherin expression and prognosis was assessed by Kaplan-Meier survival analysis and compared by log-rank test. Results The results demonstrated that p-STAT3 expression was positive in 58％ HCC patients. The expression of p-STAT3 was associated with invasion and metastasis( P = 0. 038 ), However,52％ HCC showed that E-cadherin expression reduced,it was also associated closely with invasion and metastasis ( P = 0. 001 ). In HCC, p-STAT3 expression was negatively correlated with E-cadherin expression( P = 0. 006). Survival analysis indicated that HCC patients with pSTAT3 positive expression or reduced E-cadherin expression had a significantly shorter survival duration than those with negative expression of p-STAT3 or those with normal E-cadherin expression( P = 0. 005, P = 0. 001 ). Conclusion Activated STAT3 signal and deregulated E-cadherin expression are correlated with HCC invasion and metastasis. Abnormal p-STAT3 or E-eadherin expression can serve as markers for prognosis judgment of HCC patients.关键词
癌,肝细胞/STAT3转录因子/预后Key words
carcinoma, hepatocellular/ STAT3 transcription factor/ prognosis分类
医药卫生引用本文复制引用
张传海,许戈良,荚卫东,李建生,马金良,任维华,葛勇胜,刘文斌..肝细胞癌中磷酸化STAT3与上皮型钙粘素的表达及其临床意义[J].安徽医科大学学报,2011,46(2):105-108,4.基金项目
国家自然科学基金(编号:30972893) （编号:30972893）
安徽医科大学校科研基金(编号:2010xkj079) （编号:2010xkj079）
