无机材料学报2011，Vol.26Issue(1)：49-54,6.DOI:10.3724/SP.J.1077.2011.00049
掺锶羟基磷灰石的制备与性能研究
Preparation and Property of Strontium-substituted Hydroxyapatite
摘要
Abstract
The biological HA in the body differs from that of pure HA in stoichiometry, composition, physical properties and mechanical properties, because this HA is particularly prone to ion substitution. As a cation that can substitute for calcium in the structure of hydroxyapatite, strontium provokes an increasing interest because of its beneficial effect on bone formation, and prevention of bone resorption. Here, strontium-substituted HA powders were prepared by the hydrothermal method at 180℃ for 8 h using Ca(NO3)2·4H2O, (NH4)2HPO4 and Sr(NO3)2 as reagents. X-ray diffraction, Fourier transform infrared spectroscope, transmission electron microscope, energy dispersive X-ray, and thermogravimetric-differential thermal analysis were employed to investigate the crystalline phase, chemical composition, morphology, and thermal stability of the Sr-HA. And the cytotoxicity of Sr-HA was analyzed through MTT assay. The results show that Sr is incorporated into the HA crystal structure and the crystal grain size of the Sr-HA decreases as the Sr content (under 50wt％) is increased. Moreover, the HA thermal stability decreases. However, there's no apparent difference between the pure hydroxyapatite and all of the Sr-HA groups in cytotoxicity, which may have good biocompatibility.关键词
掺锶羟基磷灰石/合成/水热法/细胞毒性分类
化学化工引用本文复制引用
李志宏,武继民,黄姝杰,关静,张西正..掺锶羟基磷灰石的制备与性能研究[J].无机材料学报,2011,26(1):49-54,6.基金项目
天津市自然科学基金(09JCYBJC14100) （09JCYBJC14100）
国家自然科学基金重点项目(10832012) （10832012）
军事医学科学院科研创新重大项目(2008ZD009) （2008ZD009）
