山东医药2011，Vol.51Issue(5)：19-20,2.
比索洛尔、赖诺普利对原发性高血压患者左室肥厚及血浆脑钠肽的影响
Effect of bisoprolol and lisinopdl on plasma brain natriuretic peptide and left ventdcular hypertrophy in hypertensive patients
侯子龙 1左兆凯 1刘芳 1熊丽燕1
作者信息
- 1. 泰山医学院附属聊城市第二人民医院,山东临清,252600
- 折叠
摘要
Abstract
Objective To investigate the effect of β-blocker and angiotension converting enzyme inhibitor (ACEI) on the level of plasma brain natriuretic peptides (BNP) in treating the elementary hypertension (EH) patients with left ventricular hypertrophy (LVH). Methods 124 EH patients were collected, and they were divided into LVH group ( n = 76)and without LVH group ( n =48) according to with or without LVH. The 76 patients with LVH were treated with bisoprolol and angiotension converting enzyme inhibitor-lisinopril for 12 months. Plasma BNP levels in two groups and A/E value and IVMI level in LVH group before or after treatment were detected. Results Compare to the without LVH group, the level of BNP significantly increased in the VH group (P ＜ 0.05). A/E value, LVMI and BNP levels significantly decreased in LVH group after 12-month treatment (P ＜ 0. 05 or ＜ 0.01 ). Plasma BNP level was positively related with LVMI ( r =0.60, P ＜0.01 ). Conclusions After treated by bisoprolol and lisinopril, the plasma BNP and LVMI in EH patients with LVH could decrease, accordingly bisoprolol and lisinopril can reverse LVH.关键词
高血压,原发性/左室肥厚/脑钠肽/比索洛尔/赖诺普利Key words
bisoprolol/ hsinopril/ left ventricular hypertrophy/ brain natriuretic peptide分类
医药卫生引用本文复制引用
侯子龙,左兆凯,刘芳,熊丽燕..比索洛尔、赖诺普利对原发性高血压患者左室肥厚及血浆脑钠肽的影响[J].山东医药,2011,51(5):19-20,2.
