山东医药2011，Vol.51Issue(6)：18-19,2.
乳腺癌组织中ER、PR、 Ps2、C-erbB-2表达与新辅助化疗疗效的关系
Relationship between expression of ER, PR, Ps2, Her-2 and neoadjuvant chemotherapy effect in breast cancer
摘要
Abstract
Objective To investigate the relationship between the expression of ER, PR, Pa2 and Her-2 and the of neoadjuvant chemotherapy in breast cancer. Methods Immunohistochemical method was used to detect the expression of ER, PR, Ps2 and C-erb2 in 50 breast cancer which received neoadjuvant chemotherapy . Results The effective rates in ER negative and PR negative groups were higher than those in ER positive and PR positive groups ( 83.3％ vs 59.4％、82.4％vs 60.6％ ); There was no significant difference of the effective rate between Her-2 overexpressed group and Her-2C non-overexpressed group(81.8％ vs 64.1％ ), and the same thing happen between Ps2 negative group and Pa2 positive group( 67.7％ vs 63.2％ ). Conclusions In the patients with breast cancer,ER 、PR negative ones are more sensitive to neoadjuvant chemotherapy. These patients may get more benefits from chemotherapy. ER, PR can be considered as predictive markers of the effective rate of neoadjuvant chemotherapy.关键词
乳腺肿瘤/乳腺癌/新辅助化疗/雌激素受体/孕激素受体/雌激素调节蛋白/C-erbB-2蛋白分类
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杨科,崔树德,李连方..乳腺癌组织中ER、PR、 Ps2、C-erbB-2表达与新辅助化疗疗效的关系[J].山东医药,2011,51(6):18-19,2.
