摘要
Abstract
Objective To study the changes of progesterone receptors A and B expression in endometrial carcinoma, and explore its clinical significance. Methods The expressions of PR, PRA and PRB were determined by immunohistochemical SP method in normal endometrium (normal group ), atypical hyperplasia endometrium (atypical hyperplasia group) and endometrioid adenocarcinoma (endometrial carcinoma group). Results Significantly lower PR levels were found in endometrial carcinoma group and atypical hyperplasia group compared with normal group ( P ＜ 0.05 ). Endometrial carcinoma group had a significantly lower expressional intensity of PR than normal and atypical hyperplasia group ( P ＜ 0.05 ). The positive rate of PRA in normal ,atypical hyperplasia and endometrial carcinoma group was 100％, 86.7％ ( 13/15), 74.5％ (41/55) ,respectively. The positive rate of PRB in three groups was 100％, 80％ (12/15) and 69.1％ (38/55) , respectively. The positive rates of PRA and PRB were both significantly lower in endometrial carcinoma group than the other two groups( P ＜ 0.05 ). 82.5％ normal endometrium expressed both of the isoforms at similar levels, which was significantly higher than that in atypical hyperplasia and endometrial carcinoma group (46.7％ ,21.8％ ,P ＜0.01 ). 24 cases( 43.6％ ) in endometrial carcinoma group expressed PRA only or a predominance of PRA ,which was significantly higher than that in normal (5 cases ,12. 5％ ,P ＜0.05)and atypical hyperplasia group(4 cases,26.7％ ,P＜0. 05). In endometrioid sdenocarcinoma, both PRA and PRB had a inveme correlation with histological grade ( P ＜ 0.05 ). The expression of PRB had relations with lymphatic metastasis and clinical stage ( P ＜ 0.05 ). Conclusion Significantly lower levels of PR, PRA and PRB can be found in endometrial carcinoma. Absence and disruption of relative PR isoform expression, especially the absence of PRB, may be involved in the pathogenesis of endometrial carcinoma.关键词
子宫肿瘤/子宫内膜癌/孕激素受体/孕激素受体A/孕激素受体B分类
医药卫生
