实用医学杂志2011，Vol.27Issue(3)：393-395,3.DOI:10.3969/j.issn.1006-5725.2011.03.013
丙泊酚对大鼠肝微粒体细胞色素酶P450的影响
Effect of propofol on liver microsomal cytochrome P450 in rats
摘要
Abstract
Objective To explore the effect of propofol on liver microsomal cytochrome P450 in rats.Methods Eighteen male SD rats were randomly assigned to receive phenobarbital of 75 mg/kg (phenobarbital group, n= 6), propofol of 3.789 mg/kg (propofol group, n= 6), or normal saline (control group, n= 6) for three days. Levels of liver microsomal proteins and P450 were detected and activity of aminopyrine N-demethylase was detemined by spectrophotometry. Results As compared with the control group, the levels of microsomal proteins and cytochrome P450 were increased in phenobarbital group and propofol group; the activity of aminopyrine N-demethylase was significantly elevated in phenobarbital group. Conclusions Propofol can induce liver microsomal cytochrome P450 in rats but has no effect on the activity of aminiopyrine N-demethylase.关键词
二异丙酚/苯巴比妥钠/P450/CYP2E1引用本文复制引用
李振洲,陈学新,陈雅儒,闫瑞,孟尽海,马汉祥,邓丽琴..丙泊酚对大鼠肝微粒体细胞色素酶P450的影响[J].实用医学杂志,2011,27(3):393-395,3.基金项目
宁夏回族自治区自然科学基金项目(编号:NZ10114) （编号:NZ10114）
