中国组织工程研究与临床康复2011，Vol.15Issue(1)：55-58,4.DOI:10.3969/j.issn.1673-8225.2011.01.012
粒细胞集落刺激因子/粒-巨噬细胞集落刺激因子联合动员异基因造血干细胞移植
Allogeneic hemopoietic stem cell transplantation using mobilization with granulocyte colony stimulating factor and granulocyte-macrophage colony stimulating factor
刘忠文 1郭建民 1杨靖 1张茵1
作者信息
- 1. 河南省人民医院血液科,河南省郑州市,450003
- 折叠
摘要
Abstract
BACKGROUND: Currently, only granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) approved by Food and Drug Administration are used for the mobilization of peripheral blood hemopoietic stem cells and G-CSF alone or in combination with GM-CSF is the predominant mobilization regiments used in the allogeneic setting,but it might cause the donors some adverse events such as bone pain, muscular soreness and fever.OBJECTIVE: To retrospectively review the clinic results of allogeneic peripheral blood hemopoietic stem cell transplantation (allo-PBSCT) using mobilization with G-CSF and GM-CSF.METHODS: From January 2004 to October 2009, a total of 51 patients with hematological malignant diseases received allo-PBSCT from human leucocyte antigen-matched sibling donors mobilized with G-CSF and GM-CSF at the Department of Hematology, Henan Provincial People's Hospital. We analyzed components in the allografts, hematopoietic reconstitution and the incidence of graft versus host diseases (GVHD).RESULTS AND CONCLUSION: After mobilizing 96 hours, the percentage of CD34+ cells in mononuclear cells was (0.97+0.13)％ and the percentage of CD34+/CD38- cells in CD34+ cells was (37.49+4.03)％. Rapid hematopoietic reconstruction posttransplantation was negatively associated with infused total CD34+ and CD34+/CD38- cell number. Incidences of Grades Ⅰ ,Ⅱ - Ⅳ acute GVHD were respectively 25.5％ and 15.7％ of patients. The incidence rates of limited and extensive chronic GVHD were 39.2％ and 21.2％ separately. These results suggest the combination regimen with GM-CSF and G-CSF appear to have a good effect in the mobilization of peripheral blood stem cells and be sufficient to ensure early hematopoietic reconstitution. The high doses of infused CD34+ and CD34+CD38- cells are likely beneficial to the prompt engraftment.关键词
粒细胞集落刺激因子/粒-巨噬细胞集落刺激因子/干细胞移植/CD34+细胞/CD34+CD38-细胞/造血干细胞分类
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刘忠文,郭建民,杨靖,张茵..粒细胞集落刺激因子/粒-巨噬细胞集落刺激因子联合动员异基因造血干细胞移植[J].中国组织工程研究与临床康复,2011,15(1):55-58,4.
