实用医学杂志2011，Vol.27Issue(4)：562-564,3.DOI:10.3969/j.issn.1006-5725.2011.04.005
乳腺癌组织中ABCG2及CD44+/CD24-细胞表达与预后的关系
Expressions of ABCG2 and CD44+/CD24- cells in breast carcinoma and their relationship with prognosis
摘要
Abstract
Objective To investigate the expressions of ABCG2 and CD44 +/CD24- cells in breast carcinoma and to discuss their relationship with prognosis. Methods The expressions of CD44+/CD24- cells and ABCG2 were measured by immunohistochemical double-staining and single-staining method respectively in 60 cases of breast carcinoma tissue , 60 cases of para-carcinoma tissue , and 30 cases of breast hyperplasia symptom tissue.Results The positive expression rates of ABCG2 were 50.00％ , 16.67％ , and 60.00％ respectively in breast carcinoma group, para-carcinoma group, and hyperplasia group respectively. And those in hreast carcinoma group and hyperplasia group were significantly higher than that in para-carcinoma group (both P＜0.01). The positive expression rates of CD44+/CD24- cells were 5.00％ , 3.33％ , and 26.67％ respectively in the three groups , and that in hyperplasia group was significantly higher than those in hreast carcinoma group and para-carcmoma group (both P ＜ 0.01). The expressions of ABCG2 and CD44+/CD24- cells were not associated with tumor size , differentiation ,clinical stages , lymphoid metastasis , relapse , and stromal lymph cell reaction ( all P ＞ 0.05 ). There was correlation between the expression of ABCG2 and tumor-free survival period (P ＜ 0.05) , but no correlation between the expression of CD44+/CD24- cells and tumor-free survival period was observed (P＞ 0.05 ). There was no correlation hetween the expressions of CD44+/CD24- cells and ABCG2 (P ＞ 0.05 ). Conclusions ABCG2-negative patients have a longer tumor-free survival period, And the CD44+/CD24- cells were found not only in breast carcinoma tissue but also in para-carcinoma tissue and hyperplasia tissue.关键词
乳腺肿瘤/CD44+/CD24-细胞/ABCG2/免疫组织化学/预后引用本文复制引用
白玲,张昶,王红霞,吉亚君,孟健,陈昊..乳腺癌组织中ABCG2及CD44+/CD24-细胞表达与预后的关系[J].实用医学杂志,2011,27(4):562-564,3.基金项目
连云港市重点人才课题项目(编号:ZC212) （编号:ZC212）
