中国组织工程研究与临床康复2011，Vol.15Issue(5)：936-939,4.DOI:10.3969/j.issn.1673-8225.2011.05.043
同一机构5年原位肝移植726例术后并发肝动脉血栓形成14例资料回顾
Hepatic artery thrombosis after orthotopic liver transplantation in 14 of 726 cases: A review in the same institute within 5 years
巫林伟 1胡安斌 1郭志勇 1邰强 1何晓顺 1鞠卫强 1王东平 1朱晓峰 1马毅 1王国栋1
作者信息
- 1. 中山大学附属第一医院器官移植科,广东省广州市,510080
- 折叠
摘要
Abstract
BACKGROUND: Hepatic artery thrombosis (HAT) is the main reason for graft loss or recipients death after liver transplantation although liver transplantation technology has been maturated.OBJECTIVE: To summarize the treatment for HAT after orthotopic liver transplantation.METHODS: A total of 726 adult patients received liver transplantation at the Department of Organ Transplantation, the First Affiliated Hospital of Sun Yat-sen University from January 2004 to December 2009 were selected. Fourteen patients suffered from HAT after the operation, the clinical data of these patients were analyzed retrospectively.RESULTS AND CONCLUSION: The incidence rate of HAT was 1.9％ (14/726), mean time of the onset was 10 days (1 -41 days)postoperatively. Six of them had acute liver function deterioration, 4 had bile leakage, 1 had hepatic abscess and 3 had no symptoms. Three patients received urgent rearteriarization, 2 received intra-arterial thrombolysis, 3 received combined urgent rearteriarization and intra-arterial thrombolysis, and 6 patients received retransplantation. Mortality rate associated with HAT was 42.9％ (6/14), 2 from biliary necrosis and secondary hepatic failure after urgent rearteriarization, 1 from recurrence of HAT and multiple organ failure after intra-arterial thrombolysis, 1 from renal failu re and severe infection after combined urgent rearteriarization and intra-arterial thrombolysis, 2 from severe infection after retransplantation. The other patients recovered and were followed up 18-66 months. Their liver grafts were all functioning well with patent artery, 2 died from tumor recu rrence at 18 and 29 month after transplantation. HAT is a severe complication after liver transplantation, which leads to graft loss and recipients' death. Rearteriarization as early as possible before irreversible biliary and liver parenchyma damage can avoid retransplantation.关键词
肝动脉血栓形成/肝移植/再血管化/溶栓/并发症分类
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巫林伟,胡安斌,郭志勇,邰强,何晓顺,鞠卫强,王东平,朱晓峰,马毅,王国栋..同一机构5年原位肝移植726例术后并发肝动脉血栓形成14例资料回顾[J].中国组织工程研究与临床康复,2011,15(5):936-939,4.
