应用化学2011，Vol.28Issue(1)：107-112,6.DOI:10.3724/SP.J.1095.2011.00195
氟喹诺酮类抗生素与磷钨酸体系的共振瑞利散射光谱研究及其分析应用
Study on Resonance Rayleigh Scattering Spectra of Phosphowolframic Acid and Fluoroquinolone Antibiotics System and Their Analytical Application
摘要
Abstract
In 5. 0 mol/L HCl buffer solution, phosphowolframic acid(Pwa) could react with moxifloxacin (MXFX) and gatifloxacin ( GTF) fluoroquinolone antibiotics ( FLQs) to form 1 · 1 ion-associated complexes respectively. The reactions resulted in great enhancement of resonance Rayleigh scattering ( RRS) and new RRS bands appear. The reaction products of the two drugs had similar spectral characteristics, and the maximum RRS wavelength was located at 320 nm. The intensities of RRS are proportional to the concentration of antibiotics, the linearity ranges of two fluoroquinolone antibiotics are 0.025 ～ 6. 0 mg/L ( MXFX) and 0. 023 ～9. 0 mg/L ( GTF) , respectively. Therefore, a new method for determination of the drugs could be developed and applied to the determination of FLQs in capsules and human urine samples. The reaction mechanism and the reasons for RRS enhancement of the system were investigated.关键词
莫西沙星/加替沙星/磷钨酸/共振瑞利散射光谱分类
化学化工引用本文复制引用
李勤,周尚,杨季冬..氟喹诺酮类抗生素与磷钨酸体系的共振瑞利散射光谱研究及其分析应用[J].应用化学,2011,28(1):107-112,6.基金项目
重庆市教委科研资助项目(KJ081306) （KJ081306）
