天然产物研究与开发2011，Vol.23Issue(1)：43-48,53,7.
纳米级南瓜肌醇提取物的制备及其降血糖作用研究
Preparation of Nanoscale Pumpkin Inositol Extract and Its Hypoglycemic Effect
摘要
Abstract
In this paper, nanoscale pumpkin inositol extract (NPIE) was prepared,then its hypoglycemic effect was evaluated in Streptozocin (STZ)-induced diabetic mice and the effect compared to common pumpkin inositol extract (CPIE). The experiment was comprised of diabetic mice treated with the low- and high- dose (250 mg/kg and 500 mg/kg) of NPIE and CPIE, respectively, positive controls with Mefformin Hydrochloride (Met), and model group administrated with distilled water. The experiment term was 30 days. The results showed that the pumpkin extract contained 3.21％ inositol and 53.21％ polysaccharide,in which the average diameter of NPIE was leas than 500 nm. After animal experiment, all groups had no influence on the acute hypoglycemic effect of normal mice and the body weight of diabetic mice;however, a significantly reduced levels of the random and fasting blood glucose and a improvement in blood glucose tolerance were noticed in the diabetic mice treated with 500 mg/kg of NPIE. And the hypoglycemic effect of NPIE was slightly lower than Met,but higher than CPIE.关键词
纳米级/南瓜肌醇/提取物/多糖/降血糖Key words
Nanoscale/ Pumpkin Inositol/ Extract/ Polysaccharide/ Hpyerglycemic分类
农业科技引用本文复制引用
陈丹青,刘华奇,李彦娜,赵萍,夏涛..纳米级南瓜肌醇提取物的制备及其降血糖作用研究[J].天然产物研究与开发,2011,23(1):43-48,53,7.基金项目
上海市农业科技成果转化项目(083919n1800) （083919n1800）
