湖北医药学院学报2011，Vol.30Issue(1)：71-73,3.
正交试验法优选苦参素缓释微球制备工艺
Preparation of Oxymatrine Sustained-release Microspheres:Optimization Using Orthogonal Design
李兢 1张洪 2李华荣1
作者信息
- 1. 武汉大学人民医院药学部,湖北,武汉,430060
- 2. 华中科技大学同济医学院附属荆州医院药学部,湖北,荆州,434020
- 折叠
摘要
Abstract
Objective To optimize the preparation method of oxymatrine sustained-release microspheres.Methods The orthogonal design was used to test the influence of four main factors in preparation,including amount of chitosan,mass ratio of oxymatrine and chitosan,amount of glutaraldehyde and emulsion cross-linking time.The drug loading and entrapment efficiency of microspheres were used for evaluation indexes.Results The optimum preparation process was the amount of chitosan with 2％ ,mass ratio of oxymatrine and chitosan with 1∶1 ,amount of glutaraldehyde with 1 mL and emulsion crosslinking time with 2 h.The drug loading and entrapment efficiency of microspheres werel2.56％ and 41.98％.Conclusion The preparation of oxymatrine sustained-release microspheres optimizated by orthogonal design could be a aimple,quick and accurate method.关键词
苦参素缓释微球/壳聚糖/正交试验/制备工艺分类
医药卫生引用本文复制引用
李兢,张洪,李华荣..正交试验法优选苦参素缓释微球制备工艺[J].湖北医药学院学报,2011,30(1):71-73,3.
