天然产物研究与开发2011，Vol.23Issue(1)：153-158,6.
红谷霉素对金黄色葡萄球菌抑菌机制的研究
Antibacterial Mechanism of Honggumycin to Staphylococcus aureus
摘要
Abstract
Honggumycin is a kind of new antibiotic. Using Staphalococcus aureus as the experimental bacterial, the antibacterial mechanism of Honggumycin was investigated. The experimental bacterial was treated with Honggumycin at the concentration of EC50 and EC90 ,with no Honggumycin as blank control. And the EPS, plasmalemma transparence, and biomolecular (DNA, RNA, and protein) were determined. The results showed that the antibacterial activity of Honggumycin to S. aureus was presented in inhibiting the synthesis of nuclei acid. The synthesis of protein and other biomolecular were restrained due to the inhibition of nuclei acid synthesis, and the plasmalemma permeability was changed. Electron mieroscope photograph showed the protoplast of S. aureus had become thin after treating with Honggumycin.关键词
红谷霉素/金黄色葡萄球菌/抑菌机制Key words
Honggumycin /Staphalococcus aureus/ antibacterial mechanism分类
生物科学引用本文复制引用
涂璇,薛秀园,涂国全..红谷霉素对金黄色葡萄球菌抑菌机制的研究[J].天然产物研究与开发,2011,23(1):153-158,6.基金项目
江西省自然科学基金项目(0630013) （0630013）
