中国组织工程研究与临床康复2011，Vol.15Issue(1)：143-146,4.DOI:10.3969/j.issn.1673-8225.2011.01.032
干细胞应力学效应机制的研究与进展
Development of mechanical mechanisms of stem cells
摘要
Abstract
BACKGROUND: Recently, studies addressing molecular basis of various cell signal transduction and regulation mechanism of relevant functions have obtained important progress, but the biological behavior of stem cells is complicated. The related signal transduction pathway and mechanism of proliferation and differentiation remain unclear.OBJECTIVE: To review relevant literatures, and to summarize the present status and application prospect of stem cell related signal pathway affected by cytomechanics.METHODS: China National Knowledge Infrastructure and PubMed database were retrieved by computer for articles concerning mechanical effect of mechanisms for stem cells published from 2005 to 2010. The key words were "stem cell, signal transduction"or "stem cell, stress". The articles on signal transduction pathway of stem cells published recently in the same field or published in the authorized journals were selected, and totally 179 articles were primarily selected. Finally, 33 articles were included in accordance with inclusion criteria.RESULTS AND CONCLUSION: Many different signal pathways had been involved in the proliferation and differentiation of stem cells. The stem cells could play an important role in the stem appreciation and differentiation which were modulated by several different signal pathways, including F-actin, Ca2+, MAPK, Wnt and Notch. The exact mechanism of mechanics signal transduction and gene expression under stress condition will be an important content in future stem cell research.关键词
机械应力/干细胞/信号转导/调控/增殖分化分类
医药卫生引用本文复制引用
包志强,任明姬,李建福..干细胞应力学效应机制的研究与进展[J].中国组织工程研究与临床康复,2011,15(1):143-146,4.基金项目
国家自然科学基金资助项目(30570708). （30570708）
