中国组织工程研究与临床康复2011，Vol.15Issue(1)：163-166,4.DOI:10.3969/j.issn.1673-8225.2011.01.037
自体骨髓间充质源神经干细胞移植应用于中枢神经系统疾病7例
Autologous transplantation of bone marrow mesenchymal cells-derived neural stem cells for treating seven patients with central nervous system diseases
曹志勇 1耿德勤 1刘涵 1单君君 1朱孟慧 1王俊明 1陈昊 1程言博 1樊红彬 1董瑞国1
作者信息
- 1. 徐州医学院附属医院神经内科,江苏省徐州市,221002
- 折叠
摘要
Abstract
BACKGROUND: Previous studies of animal models of nervous system diseases have shown that bone marrow mesenchymal cells-derived neural stem cells have a good effect on central nervous system diseases.OBJECTIVE: To observe the therapeutic effects of autologous transplantation of bone marrow mesenchymal cells-derived neural stem cells applied for central nervous system diseases.METHODS: Seven patients with central nervous system diseases were subjected to by autologous transplantation of bone marrow mesenehymal cells-derived neural stem cells from October 2008 to April 2009. Bone marrow puncture aspiration was used to collected 50-60 mL bone marrow blood, which was prepared into bone marrow mesenchymal stem cell suspension following isolation and culture in vitro. Neural stem cells were isolated and induced with self cerebrospinal fluid , and transplanted into patients by lumbar puncture via the subarachnoid cavity. Neurological impairment and side effects posttransplantation were observed prior to and following transplantation.RESULTS AND CONCLUSION: No adverse reactions were found in three patients after transplantation. The neurological function of the seven patients had been improved in 6-month follow-up. Results suggest that it is a safe, convenient and effective method to use autologous transplantation of bone marrow mesenchymal cells-derived neural stem cells to treat patients with neurological impairment induced by nervous system diseases.关键词
神经干细胞/骨髓/移植/自体/中枢神经系统疾病分类
医药卫生引用本文复制引用
曹志勇,耿德勤,刘涵,单君君,朱孟慧,王俊明,陈昊,程言博,樊红彬,董瑞国..自体骨髓间充质源神经干细胞移植应用于中枢神经系统疾病7例[J].中国组织工程研究与临床康复,2011,15(1):163-166,4.
