中国组织工程研究与临床康复2011，Vol.15Issue(3)：515-518,4.DOI:10.3969/j.issn.1673-8225.2011.03.033
影响人工骨载药微球发挥作用的因素
Factors affecting the function of drug-loaded microspheres in artificial bone
摘要
Abstract
BACKGROUND: As carriers of growth factors or genes, microspheres made with artificial biodegradable materials have been used in bone tissue engineering by many researchers. But the effect of these microspheres on bone defects repair is different,and depends on many factors.OBJECTIVE: To discuss the factors that affect the function of drug loaded microspheres in bone defect repair, and to lay a foundation for further effective application of drug loaded microspheres.METHODS: A computer-based online search of PubMed (1999-01/2010-04) and CNKI (1999-01/2010-04) was performed for related articles with the keywords "gene or growth factor, nanosphere or microsphere, bone". Thirty studies about application of growth factors- or genes-loaded microspheres were included.RESULTS AND CONCLUSION: The effect of the drug loaded microspheres is closely related to their material and diameter,surface modification, types of drug loaded and the method of these microspheres combine with artificial bone scaffold . But these factors have not been researched thoroughly and controlled well. Controlling these factors well and ensuring the effective application of drug loaded microspheres in bone tissue engineering need more research from all aspects.关键词
载药微球/生长因子/基因/人工骨/骨缺损修复分类
医药卫生引用本文复制引用
李超,方涛林,董健..影响人工骨载药微球发挥作用的因素[J].中国组织工程研究与临床康复,2011,15(3):515-518,4.基金项目
"973"国家重点基础研究发展计划子课题 2009CB930002 （）
"863"国家高技术研究发展计划 2007AA03Z313 （）
国家自然科学基金项目 30970718 （）
上海市"优秀学科带头人"计划 07XD14006. （）
