摘要
Abstract
OBJECTIVE: To summarize the application characteristics of tissue engineering technology and biomaterials in preventing sports articular cartilage injury.METHODS: A computer-based online search of Pubmed database (http://www.ncbi.nlm.nih.gov/PubMed) and VIP database (http://www.cqvip.com/) from January 1993 to October 2010 was performed for related articles, using "articular cartilage, tissue engineering technology, biomaterials" for the Chinese key words and "tissue engineering, articular cartilage, scaffold material" for the English key words, duplicated research or Meta analysis were eliminated. Twenty-three papers mainly discuss seed cells,scaffolds, cytokines and their properties in the repair of sports articular cartilage injury.RESULTS : Totally 104 studies were screened out by computer search, according to inclusion and exclusion criteria, studies regarding the seed cells and bio-scaffolds for cartilage tissue engineering, as well as cytokines for tissue engineering were summarized and analyzed. Seed cells are the primary factor restricting clinical application of tissue engineered cartilage, the common seed cells include cartilage cells, bone marrow stromal stem cells and embryonic stem cells; bio-scaffold materials includes natural materials and synthetic biodegradable polymers; the growth factors for cartilage tissue engineering include transforming growth factor, bone morphogenetic protein, fibroblast growth factor, insulin-like growth factor and so on.CONCLUSION: So far, there is no ideal materials for the seed cells and scaffold materials of engineered cartilage, as well as culture environment, the focus of future research is a kind of tissue engineered articular cartilage with good performance.However, many studies are still in the experimental stage, and some problems need to be solved, especially after tissue engineering scaffolds are implanted, whether the material degradation is synchronized with cell functioning, thus altering genetic materials, gene expression or gene mutation, their clinical application requires relevant scholars and experts to constantly practice and explore.关键词
关节软骨/组织工程/生物材料/种子细胞/细胞因子分类
医药卫生
