中国组织工程研究与临床康复2011，Vol.15Issue(3)：483-486,4.DOI:10.3969/j.issn.1673-8225.2011.03.025
骨基质明胶复合自体外周血干细胞修复骨缺损的安全性评价
Safety evaluation of bone matrix gelatin with autologous peripheral blood stem cells to repair bone defects
摘要
Abstract
BACKGROUND: Animal experiments confirmed that the immunological rejection of bone matrix gelatin (BMG) is small after transplantation and BMG can promote cartilage and bone formation in the early stage.OBJECTIVE: To study the feasibility of repairing segmental bone defects by autologous peripheral blood stem cells (APBSC)/BMG.METHODS: The patients with bone defect were divided into 2 groups in accordance with the principle of voluntary. APBSC/BMG group: APBSC/BMG was installed in the bone ends, BMG group: BMG was installed in the bone ends. In addition, external and internal fixations were performed. The positive and lateral X-ray films of the bone defect were taken after surgery.RESULTS AND CONCLUSION: In APBSC/BMG group, a great amount of new irregular bone fibrous tissues, cartilage, bone cells, bone tissues and bone trabeculae are on the surface of fracture end, with medullary cavity formed. In BMG group, a great amount of fibrous tissues, a less of new irregular bone fibrous tissues and skeletal muscles were seen on the surface of fracture,accompanied by multinucleated giant cells and a few inflammatory cells. Bony callus tissues were observed at the edge of defect area. The average cicatrization time of APBSC/BMG group was shorter than BMG group (P ＜ 0.05). There were no obvious adverse reactions found du ring the treatment. APBSC/BMG has good biocompatibility, absorbability and bone induction in the process of bone defect healing. The effect ofAPBSC/BMG is better than BMG.关键词
骨基质明胶/自体外周血干细胞/骨修复/骨折愈合/生物材料分类
医药卫生引用本文复制引用
张小舟,邹三明,冯华明,黄笃,康照利..骨基质明胶复合自体外周血干细胞修复骨缺损的安全性评价[J].中国组织工程研究与临床康复,2011,15(3):483-486,4.基金项目
湖北省卫生厅科研基金项目(JXIC36). （JXIC36）
