武警医学2011，Vol.22Issue(2)：110-112,3.
维持性血液透析患者炎性反应因子水平与左心室结构和功能的关系
Relationship between inflammatory factors and left ventricular structure and function in maintenance hemodialysis patients
摘要
Abstract
Objective To study the changes in serum levels of hs - CRP, IL - 6 and TNF - α in maintenance hemodialysis patients, to measure the indicators of structure and function of left ventricle by echocardiography, and to investigate the effects of microinflammatory reaction on left ventricular structure and function in maintenance hemodialysis patients.Method Sixty patients with uremia undergoing maintenance hemodialysis were selected as MHD group.And 20 non - dialysis patients with uremia were recruited as the control group.The serum hs -CRP,IL- 6 ,TNF-α BUN and Cr were assayed in the MHD group and the control group.Two -dimensional color Doppler echocardiography was used to measure LAD, LVDs, IVST, LVPWT,and LVEF , calculating LVMI, analyzing the relationship between the serum level of hs - CRP and the changes in left ventricular structure and function.Results (1) The serum levels of hs -CRP, IL -6, and TNF -α in the MHD group were higher than those in the control group; the difference was statistically significant( P ＜ 0.05 ).(2)LAD, LVDs, IVST, LVPWT, and LVMI in the MHD group were higher than those in the control group, while the LVEF was lower than that in the control group (P ＜0.01 ) ;the difference was statistically significant( P ＜ 0.05 ).(3)The correlation analysis indicated that hs -CRP and LAD, LVDs, IVST, LVPWT, and LVMI in MHD patients were negatively interrelated (P ＜ 0.05) ,while hs -CRP and LVEF were positively interrelated (P ＜ 0.05 ).Conclusions Maintenance hemodialysis does not improve microinflammatory state,and treatment process itself also boosts and increases microinflammation.关键词
炎性因子/左心室/维持性血液透析/微炎性反应分类
医药卫生引用本文复制引用
李辉,宋洁,李瑛,李静,张晓东,石理华..维持性血液透析患者炎性反应因子水平与左心室结构和功能的关系[J].武警医学,2011,22(2):110-112,3.基金项目
天津市自然科学基金面上项目(09JCYBJC09900) （09JCYBJC09900）
