西安交通大学学报（医学版）2011，Vol.32Issue(2)：205-207,3.
星形细胞瘤中血管生成拟态的鉴定及其临床意义
Identification of vasculogenic mimicry in astrocytoma and its clinical significance
摘要
Abstract
Objective To investigate vasculogenic mimicry (VM) in astrocytoma and its clinical significance. Methods Three-dimensional culture system of U87 cells was constructed to observe VM. The presence of VM in 65 specimens of astrocytoma was observed by immunohistochemical and histological double staining of CD34 and PAS. Results After three-dimensional culture, U87 cells remolded and fused with each other, forming wreath and network structure. The immunohistochemical and histological double staining showed that VM was present in astrocytoma. VM was not found in grade Ⅰ and Ⅱ astrocytoma. The positive rate of VM in grade Ⅳ group (7/25) was significantly higher than that in grade Ⅲ group (3/18). VM density was 8.81±2.84/HP in grade Ⅳ group and 5.55± 3.13/HP in grade Ⅲ group; it increased with the increase of malignancy. There were significant differences between the groups. Conclusion VM is present in astrocytoma and it is correlated with the malignancy.关键词
星形细胞瘤/血管生成拟态/三维培养/CD34-PAS双重染色/恶性程度分类
医药卫生引用本文复制引用
张熙,郭世文,尉春艳..星形细胞瘤中血管生成拟态的鉴定及其临床意义[J].西安交通大学学报（医学版）,2011,32(2):205-207,3.基金项目
国家自然科学基金资助项目(No.30672126) （No.30672126）
