西安交通大学学报（医学版）2011，Vol.32Issue(2)：187-189,192,4.
女贞子提取物对大鼠骨骼肌抗氧化作用和运动能力的影响
Effect of Ligustrum lucidum extract on antioxidation and exercise capacity of rat skeletal muscle
摘要
Abstract
Objective To study the effect and possible action mechanisms of Ligustrum lucidum extract on antioxidation level and motor ability of skeletal muscle of great intensity endurance training rats. Methods Totally 24 SD rats were divided into sedentary control group, exercise control group and exercise + Ligustrum lucidum group, with 8 rats in each. Rats in exercise control group had 6-week exhaustive treadmill exercise while rats in exercise + Ligustrum lucidum group had an oral administration of 400 mg/kg Ligustrum lucidum extract (2 mL) daily apart from the high-intensity treadmill training. Rats in sedentary control group and exercise control group were given the same volume of Tween-80 solution (3.82 mmol/L). After 6 weeks, rats in sedentary control group were harvested at rest, those in exercise control group and exercise + Ligustrum lucidum group were harvested after an exhaustive exercise to measure antioxidant enzyme activities as well as GSH and MDA contents in bone quadriceps.Results Quadricep antioxidant enzyme activities and GSH content were significantly higher in exercise + Ligustrum lucidum group than in exercise control group (P＜0.05 or P＜0.01). Quadricep MDA level as well as serum LDH and CK activities was significantly lower in exercise + Ligustrum lucidum group than in exercise control group (P＜0.05 or P＜0.01). Exercise + Ligustrum lucidum group had a 23.09％ prolonged exhaustive exercise time compared with exercise control group. Conclusion Supplement of Ligustrum lucidum extract can enhance antioxidant capacity and motor ability of rat skeletal muscle.关键词
女贞子提取物/骨骼肌/抗氧化作用/运动能力/大鼠分类
社会科学引用本文复制引用
戚世媛,熊正英..女贞子提取物对大鼠骨骼肌抗氧化作用和运动能力的影响[J].西安交通大学学报（医学版）,2011,32(2):187-189,192,4.基金项目
陕西省自然科学基金资助项目(No.2003C137) （No.2003C137）
