中国组织工程研究与临床康复2011，Vol.15Issue(1)：126-129,4.DOI:10.3969/j.issn.1673-8225.2011.01.028
疾病特异诱导多能干细胞距离神经退行性疾病的临床治疗还有多远
How long will the disease-specific induced pluripotent stem cells be applied in the clinical treatment of neurodegenerative diseases
摘要
Abstract
BACKGROUND: Both the medical treatments and the surgery can only relieve the symptoms but not prevent the progress of neurodegenerative diseases. Cell replacement therapy proceeds fast but its ethical problem and immune rejection also should be in consideration. However, the production of induced pluripotent stem cells provides us a new way to resolve these problems.OBJECTIVE: To review the basic situations and current treatment of neurodegenerative diseases and the possibility of the induced pluripotent stem (iPS) cells be used in regenerative medicine as a new cell resource.METHODS: The PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) and Wanfang database (http://www.wanfangdata.com.cn) were retrieved for articles published from 1995 to 2010 by computer. The English key words were "induced pluripotent stem cell, PD, ALS, SMA, degenerative disease". The Chinese key words were "stem cells, Parkinson's disease". Totally 374 papers were primarily gotten. Finally, 29 papers were selected according to the inclusion criteria.RERULTS AND CONCLUSION : Patient-specific iPS cells can obtain the same genotype which is beneficial to the elucidation of the molecular mechanism of these diseases. These cells also posses the similar multi-directional differentiation ability as embryonic stem cells, which could be induced to dopamine neurons and relieve the clinical symptoms of Parkinson's disease in animal model in vitro. The iPS cells have broad prospect in the treatment of neurodegenerative diseases.关键词
诱导多能干细胞/帕金森病/脊髓侧索硬化/脊髓性肌萎缩/神经退行性疾病分类
医药卫生引用本文复制引用
罗虎,刘渔凯,李泽桂..疾病特异诱导多能干细胞距离神经退行性疾病的临床治疗还有多远[J].中国组织工程研究与临床康复,2011,15(1):126-129,4.基金项目
第三军医大学创新基金资助项目(2007XG42). （2007XG42）
