西安交通大学学报（医学版）2011，Vol.32Issue(2)：196-200,5.
结缔组织生长因子与caspase-3在自发性高血压大鼠心肌组织中表达的增龄性变化
Expression changes of connective tissue growth factor and caspase-3 with age in the myocardial tissue of spontaneously hypertensive rats
摘要
Abstract
Objective In order to make a dynamic observation on the expression changes of connective tissue growth factor (CTGF) and caspase-3 with age in the myocardial tissue of spontaneously hypertensive rats (SHR) so as to elucidate their relationship with the pathogenesis and development of hypertensive cardiomyopathy. Methods By HE staining and immunohistochemistry of cardiac tissues we detected CTGF and caspase-3 expression changes in SHR myocardium of different weeks old. Kyoto species rats of the same age and strain and with normal blood pressure served as controls. Results In SHR CTGF expression was significantly increased with the increased weeks of age, and a large number of brown substances were found expressed in myocardial interstitial and vascular smooth muscles, with significant differences among the three groups. In SHR group the expression of caspase-3 in myocardial cells was increased with the increased weeks of age, and the number of positive cells showed a trend of significant increase, each week with significant differences among the groups. Conclusion CTGF and caspase-3 expressions change in rats with different age, blood pressure and left ventricular hypertrophy, which suggests that CTGF and caspase-3 are involved in the pathogenesis and development of hypertensive cardiomyopathy.关键词
结缔组织生长因子/半胱氨酸蛋白酶蛋白-3/自发性高血压大鼠/心肌组织/心肌病变分类
医药卫生引用本文复制引用
尚亮,张颖,牟建军..结缔组织生长因子与caspase-3在自发性高血压大鼠心肌组织中表达的增龄性变化[J].西安交通大学学报（医学版）,2011,32(2):196-200,5.基金项目
陕西省科技攻关项目(No.2006K-13-G2(2)) （No.2006K-13-G2(2）
