西安交通大学学报（医学版）2011，Vol.32Issue(2)：211-214,4.
黑素瘤抑制蛋白2和VEGF在肝癌中的表达及其临床意义
Expressions of MIA2 and VEGF in primary hepatocellular carcinoma and their clinical significance
摘要
Abstract
Objective To study the expressions of melanoma inhibitory activity-related gene 2 (MIA2) and vascular endothelial growth factor (VEGF) in primary hepatoceilular carcinoma (HCC). Methods The expressions of MIA2 and VEGF were determined by immunohistochemical staining method (SP) in 36 cases of HCC and 29 cases of the corresponding paracancerous tissues. Results The positive expression rates of MIA2 and VEGF expressions in HCC tissues were 41.7％ and 77.8％, respectively. The expression of MIA2 and VEGF in HCC tissues had a positive correlation (P＜0.05). The positive expression rates of MIA2 and VEGF in the corresponding paracancerous tissues were 93.1％ and 34.5％, respectively. There was a significant difference in MIA2 and VEGF expressions between HCC and paracancerous tissues (P ＜ 0.01 ). Conclusion MIA2 expression is decreased or vanished in HCC compared with that in adjacent noncancerous tissues, and is closely associated with the differentiation, TNM staging and metastasis of HCC. The expression of MIA2 and VEGF have the negative correlation.关键词
肝细胞性肝癌/黑素瘤抑制蛋白2/血管内皮生长因子分类
医药卫生引用本文复制引用
杨帅,杨少奇,杨力,李昭宇,王琦..黑素瘤抑制蛋白2和VEGF在肝癌中的表达及其临床意义[J].西安交通大学学报（医学版）,2011,32(2):211-214,4.基金项目
宁夏自然科学基金资助项目(NZ09134) （NZ09134）
