西安交通大学学报（医学版）2011，Vol.32Issue(2)：250-252,3.
TLR2 mRNA和TLR4 mRNA在银屑病皮损中的表达
Expression of TLR2 mRNA and TLR4 mRNA in psoriatic lesions
摘要
Abstract
Objective To detect the expression of toll-like receptor 2 (TLR2) mRNA and toll-like receptor 4 (TLR4) mRNA in psoriatic skin lesions. Methods By using in situ hybridization, TLR2 mRNA and TLR4 mRNA expression levels were detected in psoriatic lesional and normal skin tissues. Results TLR2 mRNA and TLR4 mRNA were highly expressed in the suprabasal layer of psoriatic lesions, while in normal epidermis TLR2 mRNA and TLR4 mRNA were expressed in the basal layer of epidermis. There was a significant difference between psoriatic lesion and the normal epiderm (P＜0.05), and TLR2 mRNA and TLR4 mRNA expressions were higher in psoriatic lesional epidermis than in the normal epidermis. Conclusion TLR2 and TLR4 may play a crucial role in the pathogenesis and development of psoriasis.关键词
银屑病/Toll样受体2/Toll样受体4分类
医药卫生引用本文复制引用
吴娜,郑焱,郗彦萍..TLR2 mRNA和TLR4 mRNA在银屑病皮损中的表达[J].西安交通大学学报（医学版）,2011,32(2):250-252,3.基金项目
国家自然科学基金资助项目(No.30872265 （）
No.81071299) （）
