中国动脉硬化杂志2011，Vol.19Issue(1)：23-28,6.
CETP基因启动子区多态与他汀类药物调血脂效果的关联分析
The Association Between CETP Gene Promoting Polymorphisms with the Lipid-Regulating Effects of Statins
摘要
Abstract
Aim To investigate the association between the lipid-regulating effect of statins with the CETP69G/A, -629C/A, -971G/A and - 1337C/T polymorphisms. Methods The target DNA fragments of CETP gene were amplified and analyzed by PCR-RFLP technique in 207 dyslipidemia patients treated with statins. The relationship between each SNP and each blood-fat index was analyzed by SPSS statistic software. Results The A allele was not found in the -69G/A polymorphism; After the treatment with simvastatin, the TC and LDLC decreasing extent were significantly different (P = 0. 025; P = 0. 000) between - 629C/A genotypes, respectively. The - 629AA individuals were 0. 495 mmol/L( P = 0. 020 ) higher than CC individuals in TC decreasing extent. The LDLC decreasing extent were 0.577 mmol/L and 0. 352 mmol/L (P =0.000, P =0.012) higher in -629AA and CA individuals than CC individuals; the - 1337C/T polymorphisms was associated with the rising extent of HDLC level( F = 3. 064, P = 0.044). The HDLC rising extent was gradually increased among - 1337TT,TA and AA genotypes. There was no significant difference in the change of bloodfat level between the -971G/A genotypes after the treatment with simvastatin. Conclusion The -629C/A and - 1337C/T polymorphisms were associated with the lipid-regulating effect of statins.关键词
胆固醇酯转运蛋白基因/血脂异常/单核苷酸多态性/他汀类药物分类
医药卫生引用本文复制引用
李俊涛,李果明,郭志斌,张鹏辉,郑克勤..CETP基因启动子区多态与他汀类药物调血脂效果的关联分析[J].中国动脉硬化杂志,2011,19(1):23-28,6.基金项目
广东省自然科学基金资助项目(04011388) （04011388）
