中国动脉硬化杂志2011，Vol.19Issue(1)：49-54,6.
增殖抑制基因单核苷酸多态性与原发性高血压的相关性
Association of Single Nucleotide Polymorphism of Hyperplasia Suppressor Gene and Essential Hypertension
摘要
Abstract
Aim To investigate the association between 7 single nucleotide polymorphisms in intron 2 of hyperplasia suppressor gene (HSG) and essential hypertension.Methods 500 normotensive subjects (NT group) and 930 essential hypertensive patients ( EH group) were screened and DNA was acquired from white blood cells.Real-time quantitative PCR was used for the detection of 7 SNPs in intron 2 of HSG.Results The results showed that genotypes distribution and allelic frequency of rs873457, rs2336384 and rs4846085 were significantly different (P ＜0.05) between EH group and NT group, TT∶ TC∶ CC = 21.8％∶ 46.6％∶ 31.6％/22.5％∶ 53.0％∶ 24.5％ ( rs873457), CC∶ CA∶ AA = 21.8％∶ 46.8％∶ 31.4％/22.8％∶ 52.6％∶ 24.6％ ( rs2336384), TT∶ TC∶ CC = 22.6％∶ 46.4％∶ 31.0％/23.4％∶ 51.8％∶ 24.7％ ( rs4846085 ) for genotypes distribution frequency and T∶ C = 45.1％∶ 51.0％/49.0％∶ 51.0％ (rs873457), C∶ A = 45.2％∶ 54.8％/49.1％∶ 50.9％ ( rs2336384), T∶ C = 45.8％∶ 54.2％/49.1％∶ 50.6％ ( rs4846085 ) for allelic frequency.When subgrouped by sex, the genotypes distribution and allelic frequency of all the SNP were significantly different in male (P ＜ 0.05 or P ＜ 0.01 ) but not in female groups ( P ＞ 0.05 ).Correlation analysis indicated that body mass index ( BMI), age and genotype were related with essential hypertension.Logistic regression showed that BMI and rs873457 were closely associated with blood pressure after adjusting for age.The frequency of C-G-A-A-A-C-C haplotype was significantly higher in essential hypertensive patients verse control individuals, either in entire population, in male or female group (P ＜ 0.01 for all).As for other haplotypes, most of haplotypes were only significantly different in the entire population and male subjects.Conclusion The genetie variations of HSG may be associated with essential hypertension in male Chinese.关键词
增殖抑制基因/单核苷酸多态性/原发性高血压分类
医药卫生引用本文复制引用
王佐广,牛秋丽,楼煜清,刘雅,刘洁琳,刘阔,文杰,温绍君,吴兆苏..增殖抑制基因单核苷酸多态性与原发性高血压的相关性[J].中国动脉硬化杂志,2011,19(1):49-54,6.基金项目
国家863高技术项目基金资助(2008AA02Z441) （2008AA02Z441）
北京市自然科学基金(7102045) （7102045）
