中国动脉硬化杂志2011，Vol.19Issue(1)：55-60,6.
肾移植后高血压人群中CYP3A4*1G、CYP3A5*3和MDR1C3435T基因多态性对氨氯地平降压疗效的影响
The Effect of CYP3A4*1G, CYP3A5*3 and MDR1 C3435T Gene Polymorphism on Antihy pertensive Effect of Amlodipine in Hypertensive Patients After Renal Transplantation
文娟 1黄志军 1袁洪 1邢晓为 1赵秋平 1席兰艳1
作者信息
- 1. 中南大学湘雅三医院临床药理中心,湖南省长沙市410013
- 折叠
摘要
Abstract
Aim To analyse the association of CYP3A4 * 1G, CYP3A5 * 3 and MDR1 C3435T gene polymorphisms with the antihypertensive effect of amlodipine. Methods A total of 70 patients were screened who were diagnosed as hypertension in the first year after transplantation. The patients were assigned to receive amlodipine (5 mg/d) for 4 weeks. PCB-RFLP were applied to detect CYP3A4 * 1 G, CYP3A5 * 3 and MDR1 C3435T gene polymorphism, and antihypertensive effects were analyzed according to genotype. Results Ater 4-weeks treatment, mean reductions in systolic blood pressure(SBP) and diastolic blood pressure(DBP) were 18. 8 ±6. 9 mmHg and 12. 7 ±5.4 mmHg, respectively ( P ＜ 0. 05). Patients with CYP3A5 * 3 * 3 genotype ( 15.0 ± 5.0 mmHg) had higher DBP reduction than those with CYP3A5*l*3(ll.3±5.3mmHg) andCYP3A5*1*1genotype(10.0±4.1mmHg) (P＜0.05). No significant relationship was found between CYP3A5 * 3 gene polymorphism and SBP reduction (P＞0. 05); Patients with CYP3A4 * 1G * 1G genotype (8.6 ±4. 1 mmHg) had lower DBP reduction than those with CYP3A4 * 1G * 1 genotype( 13.2 ± 5.2 mmHg) and CYP3 A4 * 1 * 1 genotype ( 13. 1 ± 5.5 mmHg) ( P ＜ 0. 05 ). No significant relationship was found between CYP3A5 * 3 gene polymorphism and SBP reduction (P ＞0. 05); And no significant relationship was found between MDR1 C3435T and BP reduction (P ＞ 0. 05 ). A linkage disequilibrium exists between CYP3A4 * 1G and CYP3A5 * 3 allele, GGGG, AAAA and AGAG were the most common combination. Patients with GGGG genotype can reach higher DBP reduction than other ones. Conclusion CYP3A5 * 3 and CYP3A4 * 1G gene polymorphisms can affect antihy-pertensive effect of amlodipine in hypertensive patients after renal transplantation, DBP reduction in patients with CYP3 A5* 3 * 3 genotype is higher, and DBP reduction in patients with CYP3A4 * 1G * 1G genotype is lower compared with other genotypes. Patients with GGGG genotype have higher DBP reduction in all the haplotypes composed by CYP3A4 * 1G and CYP3A5 * 3. MDR1 3435T gene polymorphism was not found to be related to the effect.关键词
肾移植/高血压/氨氯地平/基因多态性/CYP3A4/CYP3A5/MDR1分类
医药卫生引用本文复制引用
文娟,黄志军,袁洪,邢晓为,赵秋平,席兰艳..肾移植后高血压人群中CYP3A4*1G、CYP3A5*3和MDR1C3435T基因多态性对氨氯地平降压疗效的影响[J].中国动脉硬化杂志,2011,19(1):55-60,6.
