中国临床医学2011，Vol.18Issue(1)：35-37,3.
PTEN 及 Survivin 在卵巢上皮性癌中的表达及相关性
Expression and Correlation of PTEN and Survivn in Ovarian Epithelial Carcinoma
摘要
Abstract
Objective: To investigate the expression and correlation of PTEN and survivin in ovarian epithelia carcinoma.Methods: The expression of PTEN and survivin in 38 cases of ovarian epithelial carcinoma,21 benign tumors and 20 normal ovarian tissue were determined by S-P immunohistochemical method.Results: The positive rate of PTEN in the ovarian carcer tissue was lower than in the normal and benign ocarian tumors(P＜0.05).Survivin expression trend was opposite to that of PTEN.In ovarian epithelia carcinoma, negative correlation between expression of PTEN and survivin was abserved(r = -0.527,P = 0.001 ).No different expression of PTEN and survivin among histological types or ages was found (P＞0.05).The expression level of PTEN and survivin were associated with differentiation, clinic stage( P＜0.05 ).Conclusions: PTEN and survivin may play an important role in the initation,development and prognosis of ovarian epithelia carcinoma and the combination of PTEN and survivin expression may be helpful in predicting the malignant degree and prognosis of ovarian epithelia cancer.关键词
卵巢上皮性癌/PTEN基因/Survivin基因分类
医药卫生引用本文复制引用
刘志慧,顾振鹏,马立新,王桂红,刘晶晶,姚丽娟..PTEN 及 Survivin 在卵巢上皮性癌中的表达及相关性[J].中国临床医学,2011,18(1):35-37,3.基金项目
山东省保健医学科研项目(编号:2007BZ20) （编号:2007BZ20）
