中国临床医学2011，Vol.18Issue(1)：29-31,3.
姜黄素对肾小球系膜细胞过氧化物酶体增殖物激活受体γ基因表达的影响
Curcumin on Gene Expression of PPAR-γ in Glomerulus Mesangial Cells
摘要
Abstract
Objective:Observe effects of Curcumin on gene expression of the peroxisome proliferator-activate receptors gamma (PPAR-γ) mRNA in glomerulus mesangial cells. Methods: High glucose concentration and Curcumin solutions of different concentrations were incubated with glomerulus mesangial cells by using reverse transcription-polymerase chain reaction (RT-PCR)to detect expression of PPAR-γmRNA of cells. Resuls: The expression of PPAR-γmRNA in glomerulus mesangial cells of the group of pure high glucose concentration was lower than the normal group (0. 394 ± 0. 026 vs. 0. 995 ± 0. 016, P＜0. 01 ).When concentration of Curcumin reaches 100mg/L, the ratio of integral optical density of its PPAR-γmRNA was, higher than that of Gurcunin 25 mg/L group (0. 701 ± 0.04 vs. 0. 541 ± 0. 018, P＜0.01 ) and it was significant higher than that of Curcumin 6. 25 mg/L group (0. 432 ± 0. 024, P＜0.01 ). Conclusions: Curcumin will antagonize inhibition effect of high glucose concentration on gene expression of PPAR-γ in glomerulus mesangial cells, and increase the expression level of PPAR-γmRNA.关键词
肾小球系膜细胞/过氧化物酶体增殖物激活受体γ/姜黄素分类
医药卫生引用本文复制引用
王志宏,朱爱国,杨晶涵,常云华,赵娜..姜黄素对肾小球系膜细胞过氧化物酶体增殖物激活受体γ基因表达的影响[J].中国临床医学,2011,18(1):29-31,3.基金项目
吉林省科技厅资助项目(编号:200505206) （编号:200505206）
