中国免疫学杂志2011，Vol.27Issue(2)：130-134,5.DOI:10.3969/j.issn.1000-484X.2011.02.008
龙牙楤木多糖抗肿瘤活性及对荷瘤小鼠免疫功能的影响
Antitumor activity of polysaccharide from Aralia elata Seem and the effect on immune functions in tumor-bearing mice
摘要
Abstract
Objective: To elucidate the antitumor activity of polysaccharide from Aralia elata Seem (AEPS) and the effect on immune functions in tumor-beating mice. Methods: The in vivo inhibition of AEPS on growth of tumor was performed by inoculation of S180 sarcoma cells into ICR mice, while in vitro activity against tumor cells was assayed by the growth inhibition of cell lines of S180 sarcoma, A549 and SMMC-7721. The effects of AEPS on immune function were evaluated by the influence on the thymus, spleen, and the number of lymphocytes in blood stream, and the influence on proliferation of lymphocytes as well as on the killing activity of NK cells. Results: AEPS inhibited in vivo S180 sarcoma growth with the highest inhibitory rate of 57.68％ at a concentration of 75 mg/(kg·d). AEPS also displayed in vitro activity against the tested cell lines with the highest inhibitory rate being more than 60％. AEPS was found to affect the immune function in mice, including increasing the weight of thymus, spleen, and the number of lymphocytes in the blood stream, accelerating the proliferation of lymphocytes, enhancing the killing activity of NK cells and macrophages. Conclusion: AEPS is an effective antitumor agent. It inhibites the tumor cells directly and hence the growth of tumor. AEPS inhibits significantly the growth of tumor by upregulating the activity of immunocytes.关键词
龙牙楤木多糖/抗肿瘤/免疫功能分类
医药卫生引用本文复制引用
王丽君,姜虹..龙牙楤木多糖抗肿瘤活性及对荷瘤小鼠免疫功能的影响[J].中国免疫学杂志,2011,27(2):130-134,5.基金项目
本文为吉林省科技厅资助项目(20080913) （20080913）
