摘要
Abstract
Objective: To study the effect of low-dose ketamine combined buprenorphine for the elderly during laparoscopic cholecystectomy(LC) after analgesia. Methods: Fourty elderly patients with LC operation, aged 60 to 72years, were randomly classified two groups: Group D (n = 20)which apply Dexmedetomidine 1.0μg/kg in 10 min before anesthesia, and Group C (n = 20)groups received midazolam 50μg/kg. Two groups in postoperative analgesia in the same manner: fentanyl 16μg · kg that were diluted to 100 mL normal saline into the PCA pump, injection rate of 2 mL/h single-controlled volume 0. 5 mL, lockout time 15 min, monitored visual analogue scale(VAS), mean arterial pressure, ramsay sedation score and observed hypersomina,dizziness, nausea, vomiting, respiratory depression and other adverse reactions. Results: Multiple times and Group D VAS scores were significantly lower than the group C(P＜0.05), and ramsay scores were significantly higher than the Group C (P ＜0. 05), OAA/S scores were significantly higher than the Group C (P＜0.05). The other adverse reactions, including dizziness, respiratory inhibition,need to increase the number of cases serving painkillers, Group D were lower than the Group C.Nausea and vomiting of no significant difference between the two groups. Conclusions: Dexmedetomidine as anesthesia adjuvants have preemptive analgesia for elderly postoperative analgesia and its side effects with vomiting, respiratory inhibition are relatively small and reduces postoperative opioid consumption,关键词
DEX/老年人/超前镇痛分类
医药卫生
