中国美容医学2011，Vol.20Issue(2)：229-231,3.
Ⅰ型IP3受体在自体中厚移植皮片中的表达
Expression of IP3R1 in human split-thickness skin autografts
摘要
Abstract
Objective To investigate the expression of IP3R1 in human split-thickness skin autografts and to recognize the role of calcium signal transduction in hyperpigmented process of the skin autografts. Methods Immunohistoehemieal technique was adopted to detect the expression of IP3R1 in the split-thickness grafted skin,the normal skin around the recipient area and normal skin separately and statistics was used to analyze the data. Results The expression of IP3R1 was located in endochylema of melanocytes and keratinocytes in the basilar part of epidermis.The expression of IP3R1 in most of the split-thickness grafted skin was significantly higher than the control skin, The positive integral optical density of IP3R1 in the split-thickness skin grafts (0.47±0.07) was significantly higher than that in the normal skin around the recipient site (0.21±0.09) and in the normal skin around the donor site (O.19±O.08).Showing statistically significant difference (P＜O.O5).The expression of IP3R1 in the normal skin of the donor area was no statistic remarkably differences compared to the normal skin around the recipient area. Conclusion The results indicate that the expression of IP3R1 may markedly increase in the split-thickness grafted skin and correlate with its pigmentation after the skin autograft. Calcium signal transduction may play an important role in hyperpigmented process of the skin autograft.关键词
IP3受体/钙信号转导/自体移植皮片/过度色素沉着分类
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戴海英,薛春雨,邢新,梅香,张培培,李鸣..Ⅰ型IP3受体在自体中厚移植皮片中的表达[J].中国美容医学,2011,20(2):229-231,3.基金项目
国家自然基金资助项目(项目批号:30872693) （项目批号:30872693）
