中国比较医学杂志2011，Vol.21Issue(2)：51-55,5.DOI:10.3969/j.issn.1671.7856.2011.02.12
贝类毒素监测的动物试验优化及替代方法
Optimization of Animal Testing and Alternative Methods for Shellfish Toxin Monitoring
摘要
Abstract
Objective Shellfish toxins are not only threatening to quality of marine aquatic products but also become a potential threat to human health. As the structure diversity and function mechanism complexity, the monitoring programs of shellfish toxins using animal models are costly,difficult to quantitate and not meet 3R principles. There is a pressing need to develop new methods to reduce quantity of used animals and to relieve animal distress. Recently, many new assays based on action mechanisms have been developed including functional, immunological, chemical analysis and biosensor methods. These methods promote the efficacy of shellfish toxin monitoring,and will be accepted by administration for regulation programs provided these approaches be scientifically validated and standardized.关键词
贝类毒素/动物实验/替代方法分类
医药卫生引用本文复制引用
程树军,黄韧,刘慧智..贝类毒素监测的动物试验优化及替代方法[J].中国比较医学杂志,2011,21(2):51-55,5.基金项目
广东省科技计划项目(2009B060300013). （2009B060300013）
