中国比较医学杂志2011，Vol.21Issue(2)：20-22,后插2,4.DOI:10.3969/j.issn.1671.7856.2011.02.05
甲型H1N1流感病毒感染小鼠的发病机制
Pathogenesis of Influenza A(H1N1) Virus in Infected Mice
摘要
Abstract
Objective To study the mechanism of the influenza virus infection in BALB/c mice with A/California/7/2009Influenza H1N1 virus.Methods Sixty BALB/c mice were randomly divided into 2 groups:experimental group and control group, each group consisted of 30 mice.The CA7 influenza virus was used to establish influenza models.The expressions of lung IL-6, TNF-α, and IL-2 in experimental group of 5th day control group were detected by enzyme linked immunosorbent assay(ELISA).Results The lung tissue IL-6,TNF-α levels were significantly higher, IL-2 levels were significantly lower than that in the control group, the differences were significant ( P ＜ 0.05 ).Conclusions The cytokines IL-2,IL-6 and TNF-α may participate in the whole process of influenza A H1N1 virus infection and their lung levels are positively correlated with the severity of the disease.关键词
A/California/7/2009/BALB/c小鼠/发病机制/细胞因子分类
医药卫生引用本文复制引用
鲍琳琳,孙惠惠,占玲俊,许黎黎,邓巍,李枫棣,吕琦,朱华,秦川..甲型H1N1流感病毒感染小鼠的发病机制[J].中国比较医学杂志,2011,21(2):20-22,后插2,4.基金项目
科技重大专项-艾滋病和病毒性肝炎等重大传染病防治:2009ZX10004-402,009ZX10004-016 （）
卫生公益性行业科研专项项目:200802036 （）
中央级公益性科研院所基本科研业务费:DWS200810. （）
