针刺研究2011，Vol.36Issue(1)：12-17,6.
电针介入对痛经模型大鼠子宫微循环的影响
Effect of Electroacupuncture on the Uterine Microcirculation in Dysmenorrhea Rats
摘要
Abstract
Objective To observe the effect of electroacupuncture (EA) on uterine microcirculation in dysmenorrhea rats so as to investigate its mechanism underlying relieving primary dysmenorrheal (PD). Methods Female SD rats undergoing diestrus were randomly divided into saline control, model, Sanyinjiao(SP 6), Xuanzhong(GB 39) and non-acupoint groups, with 6 rats in each. PD model was established by subcutaneous injection of estradiol benzoate for 10 days and intra-peritoneal injection of oxytocin (2 U) 1 h after the last estradiol injection. EA (2 Hz/100 Hz, 1 - 1.5 mA) was applied to the above-mentioned acupoints and non-acupoint area for 20 minutes. Numbers and diameters of the uterine microvessels (11 - 100 μm) and capillaries (≤ 10 μm), and the state of the uterine microcirculation were observed by using a Cold Light Microcirculation Detector. Results In comparison with the saline control group, the numbers and diameters of uterine microvessels and capillaries at the correspon ding time-points 5 min, 10 min and 20 min were decreased significantly in the model group ( P＜0.05, P＜0.01 ). While compared with the model group, the numbers and diameters of uterine microvessels and capillaries at 20 min after EA in the SP 6 group were increased significantly (P＜0.05). The diameter of uterus capillaries of SP 6 group was significantly bigger than that of the nonacupoint group at the time-point 20 min (P＜0.05). No significant differences were found among the SP 6, GB 39 and non-acupoint groups in the diameter of uterine microvessels (P＞0.05). Conclusion EA of SP 6 can effectively increase the number of uterine microvessels and capillaries and the diameter of the uterine microvessels and capillaries in PD rats, which may contribute to its effect in relieving dysmenorrhea by improving uterine microcirculation.关键词
痛经/子宫微循环/电针/三阴交/悬钟分类
生物科学引用本文复制引用
李春华,赵稚芳,嵇波,任晓暄,郭孟玮,丁喜艳,孙琳琳,张露芬,朱江..电针介入对痛经模型大鼠子宫微循环的影响[J].针刺研究,2011,36(1):12-17,6.基金项目
国家重点基础研究发展计划课题(2006 CB 504503)、国家中医药管理局针灸特色疗法评价重点研究室及针灸生物学三级实验室 （2006 CB 504503）
