中国药理学通报2011，Vol.27Issue(3)：436-439,4.
大鼠嗅球切除抑郁症动物模型的改进与评价
Improvement and evaluation of olfactory bulbectomized rats as a model of depression
摘要
Abstract
Aim To explore the validity and reliabilty of olfacto ry hulbectomized( OB )rats as a model of depression. Methods Olfactory bulbectomy was induced by the removal of olfactory bulb using a blunt needle and a vacuum pump,2 weeks after surgery, the fluoxetine(10 mg · kg-1 ,ig ) and vehicle were given to olfactory bulbectomized rats and sham-operated rats for 2 weeks.Then open-field activity levels, saccharose preference levels and and avoidance test were measured to olfactory bulbectomized rats and sham-operated rats. Results Olfactory bulbectomized rats exhibited higher activity levels, lower sucrose preference levels and step-down passive avoidance than sham-operated rats. Chronic fluoxetine treatment(once daily for 2 weeks )attenuated all of these OB-associated changes. Conclusion OB rats exhibited alteration in behavior, which was reversed following chronic fluoxetine administration. These results indicated that we successfully established olfactory bulhectomized rats as a model of depression.关键词
抑郁症/抑郁症动物模型/嗅球切除/开场实验/蔗糖饮水/逃避实验分类
医药卫生引用本文复制引用
陈红霞,张黎明,薛瑞,张有志,袁莉,王心正,龚正华,李云峰..大鼠嗅球切除抑郁症动物模型的改进与评价[J].中国药理学通报,2011,27(3):436-439,4.基金项目
国家高技术研究发展计划(863计划)资助项目(No 2008AA02Z402) （863计划）
国家重点基础研究发展计划(973计划)资助项目(No 2007CB512307) （973计划）
国家自然科学基金项目(No 81001653,81072624) （No 81001653,81072624）
全军医药卫生科研基金(No 06MA304) （No 06MA304）
