中国感染控制杂志2011，Vol.10Issue(1)：5-8,4.
外源性IP-10对流感病毒及呼吸道合胞病毒感染小鼠肺病理学影响
The effect of exogenous IP-10 on mice's pulmonary pathology induced by influenza virus and respiratory syncytial virus
摘要
Abstract
Objective To study the effect of γ interferon-inducible protein 10 (IP-10) on pulmonary pathological changes in mice infected with influenza virus (IV) or respiratory syncytial virus(RSV). Methods Pulmonary pathological changes in mice infected with IV or RSV after being administered IP-10 were compared with mice infected with IV or RSV alone, normal control and only IP-10 administration mice were set up. Results The mice infected with IV or RSV after receiving IP-10 developed severe pulmonary inflammation, mice infected with IV or RSV alone also developed interstitial pneumonia, but less serious than the mice infected with IV or RSV receiving IP-10, there were significant difference between the two respectively (t = - 12. 56;t = -5. 60, both P＜0. 01). After being administered IP-10, mice infected with IV was more serious than the mice infected with RSV, there was significant difference in pathological scores of interstitial pneumonia (t = 7. 73, P＜0. 01 ). Conclusion IP-1 0 is an important chemokine which has great effect on the severity of pneumonia caused by IV or RSV.关键词
流感病毒/呼吸道合胞病毒/γ干扰素诱导蛋白10/肺炎/病理学/流行性感冒/病毒感染分类
医药卫生引用本文复制引用
金红,车海龙,王冬,赵月..外源性IP-10对流感病毒及呼吸道合胞病毒感染小鼠肺病理学影响[J].中国感染控制杂志,2011,10(1):5-8,4.基金项目
辽宁省自然科学基金项目(20072098) （20072098）
