南方医科大学学报2011，Vol.31Issue(2)：285-288,4.
EGFR和c-Met基因的相对拷贝数在非小细胞肺癌预后中的意义
Detection of epidermal growth factor receptor and c-Met gene copies for prognostic evaluation of non-small cell lung cancer
摘要
Abstract
Objective To investigate the role of epidermal growth factor receptor (EGFR) and c-Met in the oncogenesis, development and prognosis of non-small cell lung cancer (NSCLC). Methods The relative copy numbers of EGFR and c-Met mRNA were detected in 61 cases of NSCLC by fluorescent RT-PCR, and the correlation between EGFR and c-Met as well as their correlation to the clinicopathological data of the patients were analyzed. A survival analysis was also performed in relation to EGFR and c-Met expressions. Results The relative copy numbers of EGFR and c-Met were positively correlated (r=0.352, P=0.005). The levels of these two genes in smokers were 0.15 and 0.14, respectively, significantly higher than those in non-smokers (P0.05); their levels were 0.16 and 0.14 in adenocarcinoma, respectively, significantly higher than those in squamous carcinomas (P0.05). In patients with squamous carcinomas, a higher level of EGFR and c-Met DNA copies was associated with poorer prognosis, and Log Rank analysis indicated a survival difference in relation to EGFR and c-Met DNA copies (P=0.015, P=0.046). Conclusion EGFR and c-Met may interact in a synergistic manner in the oncogenesis and development of NSCLC, and may help in the prognostic evaluation of squamous carcinomas.关键词
非小细胞肺癌/表皮生长因子受体/肝细胞生长因子受体/实时定量PCRKey words
non small cell lung cancer/ epidermal growth factor receptor/ c-Met/ real-time PCR分类
医药卫生引用本文复制引用
艾婷,王宁,宋丽萍..EGFR和c-Met基因的相对拷贝数在非小细胞肺癌预后中的意义[J].南方医科大学学报,2011,31(2):285-288,4.基金项目
陕西省卫生厅科学研究基金(08D28) （08D28）
