南方医科大学学报2011，Vol.31Issue(2)：277-279,3.
Wistar大鼠C6胶质瘤脑移植模型的应用
Establishment of a Wistar rat model bearing brain glioma C6 cells and its experimental application
摘要
Abstract
Objective To establish a rat model bearing brain glioma and investigate the optimal conditions for its experimental application. Methods C6 cells were implanted into the unilateral brain hemisphere of 20 Wistar rats. The growth behaviors of the brain tumor and behavioral changes of the rats were observed at different time points after the implantation. Results On day 3 after the implantation, only a slight increase of signal intensity was observed on T2-weighted images. By day 5, the tumor became visible in 15/18 of the rats in at least two sections. By day 11,16/ 18 of the rats showed space-occupying effect in the brain, and by day 14, the tumor occupied over 1/2 of the hemisphere in 14/18 of the rats. By day 20, 14/18 of the rats showed a tumor mass occupying over 2/3 of the hemisphere, and some tumor cells had migrated into the contralateral hemisphere. Conclusion In this model of brain glioma, the optimal time widow for experiment is between 14 and 18 days after the cell implantation. The cell density and viability for implantation and the site of implantation may also affect the experimental time widow.关键词
C6胶质瘤/移植模型/疾病模型/动物/磁共振成像/实验时间窗Key words
C6 glioma/ implantation model/ disease model, animal/ magnetic resonance imaging/ experimental time widow分类
医药卫生引用本文复制引用
易林华,傅相平,李安民,闫润民..Wistar大鼠C6胶质瘤脑移植模型的应用[J].南方医科大学学报,2011,31(2):277-279,3.基金项目
国家自然科学基金(30772245) （30772245）
