南方医科大学学报2011，Vol.31Issue(2)：365-368,4.
长方案垂体降调节行IVF-ET时雌二醇水平变化的意义
Value of serum estradiol concentration in predicting the clinical outcome of IVF-ET in patients receiving long protocol of GnRHa
摘要
Abstract
Objective To investigate the value of serum estradiol increment and serum estradiol/follicles on the day of hCG administration in predicting the clinical outcomes of in vitro fertilization-embryo transfer (IVF-ET). Methods A retrospective analysis of the IVF-ET data was conducted involving 121 patients who received a long gonadotrophin-releasing hormone agonist (GnRHa) protocol. According to the increment of serum estradiol on the day of hCG administration (relative to the level on the day before hCG administration), the patients were divided into 3 groups (Al, A2 and A3) with a increment ratio below 30%, between 30% and 50%, and over 50%, respectively. In addition, according to the ratio of serum estradiol level on hCG day to mature follicle (diameter>14 mm) number, these patients were divided into three groups (Bl, B2 and B3) with the ratio below 250 pg/ml, between 250 and 350 gp/ ml, and over 350 pg/ml, respectively. The hormonal characteristics and clinical outcomes of the IVF-ET cycles were analyzed comparatively. Results Both the clinical pregnancy rate (71.05%) and embryo implantation rate (52.63%) were significantly higher in group A3 than in groups Al and A2 (PO.05). The best clinical pregnancy rate (67.86%) and embryo implantation rate (49.14%) were significantly higher in group B2 than in groups Bl and B3 (P<0.05). Conclusion The variation of serum estradiol shows an important impact on the clinical outcomes of IVF-ET in patients receiving long GnRH-a protocol. Favorable outcomes can be expected with a hCG day serum estradiol increment ratio above 50% and Ez/follicle ratio between 250 and 350 pg/ml.关键词
体外受精-胚胎移植/长方案垂体降调节/hCG注射日/雌二醇/临床结局Key words
in vitro fertilization-embryo transfer/ long GnRH-a protocol/ hCG administration day/ estradiol/ clinical outcomes分类
医药卫生引用本文复制引用
倪郝,陈雷宁,全松,李红,华芮,高瑞花,陈思梅,罗琛..长方案垂体降调节行IVF-ET时雌二醇水平变化的意义[J].南方医科大学学报,2011,31(2):365-368,4.基金项目
广东省自然科学基金(9151051501000066) （9151051501000066）
