南方医科大学学报2011，Vol.31Issue(1)：90-92,3.
补肾活血饮对帕金森病模型小鼠脑组织一氧化氮及α-肿瘤坏死因子、γ-干扰素的影响
Effect of Bushenhuoxue Yin on cerebral levels of nitric oxide, tumor necrosis factor-α and interferon-γ in a mouse model of Parkinson disease
摘要
Abstract
Objective To observe the effects of Bushenhuoxue Yin (BSHXY), a compound traditional Chinese herbal medicine, on nitric oxide (NO), tumor necrosis factor-α (TNF-α) and interferon-γ (EFN-γ) levels in the brain of a mouse model of Parkinson disease (PD). Methods Forty-five C57BL/6 mice were randomized into MPTP-induced PD model group, BSHXY treatment group and normal control group. The contents of NO and the two cytokines in the brain tissue of the mice were determined by spectroscopy and enzyme-linked immunosorbent assay, respectively. Results The concentration of NO in the brain tissue of the PD model group was 5.93±0.79 μmol/g.protein, significantly higher than that in BSHXY group (P<0.01) and normal control group (P<0.01). The levels of TNF-α and IFN-γ in the PD model group were 0.36+0.11 ng/L and 0.83+0.25 ng/L, respectively, also higher than those in the other two groups (P<0.01 or 0.001). But BSHXY group and the normal control group showed no significant differences in the levels of NO, TNF-α and IFN-γ (P>0.05). Conclusion The therapeutic effect of BSHXY on PD is partially attributed to decreased content of NO, TNF-α and IFN-γ in the brain.关键词
帕金森病/补肾活血饮/一氧化氮/肿瘤坏死因子-α/干扰素-γKey words
Parkinson disease/ Bushenhuoxue Yin/ nitric oxide/ tumor necrosis factor-α/ interferon-γ分类
医药卫生引用本文复制引用
李绍旦,刘毅,杨明会..补肾活血饮对帕金森病模型小鼠脑组织一氧化氮及α-肿瘤坏死因子、γ-干扰素的影响[J].南方医科大学学报,2011,31(1):90-92,3.基金项目
国家自然科学基金(30672762) （30672762）
