南方医科大学学报2011，Vol.31Issue(1)：103-107,5.
新型右美沙芬咀嚼胶给药系统的药代动力学研究
Pharmacokinetic study of a new chewing gum dextromethorphan delivery system
摘要
Abstract
Objective To establish an high-performance liquid chromatography (HPLC)-based method for analysis of the pharmacokinetics and relative bioavailability of dextromethorphan chewing gum tablets in rabbits. Methods The pharmacokinetic parameters and the relative bioavailability of dextromethorphan chewing gum preparation in rabbits were compared with those of the commercially available chewing dextromethorphan tablets using 3P97 software. Results Pharmacokinetic analysis of the new dextromethorphan chewing gum tablets showed a AUC of 488.76±175.00 ng Ml-1 H, Cmax of 95.45±17.53 ng/ml, and to. Of 1.83±0.57 h as compared with the corresponding parameters of 370.13± 90.56 ng Ml'.h, 174.00±47.88 ng - ml, and 1.04±0.14 h for the commercially available chewing tablets. The relative bioavailability of the new chewing gum medicine system was (140.73 ± 65.91)% . Conclusion The new dextromethorphan chewing gum preparation shows an increased AUC(0-), decreased Gmax, and prolonged tmax in comparison with the commercially available chewing tablets, with also a greatly enhanced relative bioavailability.关键词
右美沙芬/新型咀嚼胶递药系统/生物利用度/药代动力学Key words
dextromethorphan/ new chewing gum medicine system/ relative bioavailability/ pharmacokinetics分类
医药卫生引用本文复制引用
刘娟,谭群友,刘碧林,徐美玲,赵春景,张景勍..新型右美沙芬咀嚼胶给药系统的药代动力学研究[J].南方医科大学学报,2011,31(1):103-107,5.基金项目
教育部博士点基金(20095503120008) （20095503120008）
重庆市教育委员会首批高等学校优秀人才资助(KJ090308) （KJ090308）
