南方医科大学学报2011，Vol.31Issue(1)：155-159,5.
前列腺癌中血管内皮生长因子-C、血管内皮生长因子受体-3的表达与病理分级的相关性
Correlation of the expressions of VEGF-C and VEGFR-3 to the pathological grade of prostate cancer
摘要
Abstract
Objective To investigate the correlation of the expression of VEGF-C and VEGFR-3 to the pathological grade of human prostate cancer. Methods Immunohistochemistry was used to detect the expression of VEGF-C and VEGFR-3 in 25 cases of prostate cancer tissues. Results The total positivity rates of VEGF-C and VEGFR-3 were 80% and 76% in these cancer tissues, respectively. The positivity rates of VEGF-C was 94.7% in the 19 cases with Gleason scores no less than 6 (group I), significantly higher than the rate (33%) in the 6 cases with Gleason scores between 4 and 6 (group II) (PO.01). The positivity rates for VEGFR-3 also showed a significant difference between groups I and II (89.5% vs 33.3%, P<0.05). The expression level of VEGF-C was correlated to the Gleason score of prostate cancer (R-0.436, P<0.05), and the correlation between VEGFR-3 and the Gleason score was even more obvious (R=0.608, P<0.01). Their expressions, however, did not show any correlations to the patient's age, PSA or the volume of the prostate. Conclusion VEGF-C and VEGFR-3 may serve as new markers for evaluating the malignancy of prostate cancer with Gleason score not less than 4.关键词
前列腺癌/血管内皮生长因子-C/血管内皮生长因子受体3/Gleason评分Key words
prostate cancer/ VEGF-C/ VEGFR-3/ Gleason score分类
医药卫生引用本文复制引用
陈虎,赵国平,肖宁新,夏强,赖建生,郑东升,赵振华,辛玉宏..前列腺癌中血管内皮生长因子-C、血管内皮生长因子受体-3的表达与病理分级的相关性[J].南方医科大学学报,2011,31(1):155-159,5.基金项目
江门市科技计划项目(A2008129) （A2008129）
