组织工程与重建外科杂志2011，Vol.7Issue(1)：41-44,4.DOI:10.3969/j.issn.1673-0364.2011.01.012
胰岛素样生长因子和胰岛素样生长因子结合蛋白在软骨细胞生长和发育过程中的调控作用研究进展
The Functional Role of Insulin-Like Growth Factors (IGF) and Insulin-Like Growth Factor-Bingding Proteins(IGFBP) in Chondrocytes Growth and Development
摘要
Abstract
Insulin-like growth factors (IGFs) are important growth factors regulating body growth and development especially on endochondral ossification.IGF-Ⅰ involves in chondrogenesis of mesenchymal stem cells and maintenance of mature cartilage.Insulin-like growth factor-binding proteins (IGFBPs) represent a evolutionarily conservative protein family including 6 independent family members: IGFBP1,2,3,4,5,6.They regulate functions of IGFs, exert functions of storage and transport of IGFs and have some IGF independent actions.IGFBPs play an important role in regulating cartilage development too.The regulatory role of IGFs and IGFBPs on chondrocytes growth and development were reviewed.The references for cartilage tissue engineering were provided.关键词
胰岛素样生长因子/胰岛素样生长因子结合蛋白/成软骨作用/软骨组织工程分类
生物科学引用本文复制引用
刘瑾春,刘霞..胰岛素样生长因子和胰岛素样生长因子结合蛋白在软骨细胞生长和发育过程中的调控作用研究进展[J].组织工程与重建外科杂志,2011,7(1):41-44,4.基金项目
国家自然科学基金青年科学基金项目(30801192). （30801192）
