中国实用儿科杂志2011，Vol.26Issue(2)：118-120,3.
不同中效糖皮质激素诱导缓解儿童肾病综合征的疗效观察
The different lente glucocorticoid effect of remission induction on children with nephrotic syndrome.
张碧丽 1李琛 2林书祥 3王文红 1李莉 1张瑄
1范树颖 1杜悦新1
作者信息
- 1. 天津市儿童医院肾内科,天津,300074
- 2. 河北省沧州市中心医院儿科,河北沧州,061001
- 3. 天津市儿童医院儿研所,天津,300074
- 折叠
摘要
Abstract
Objective To investigate the effects of different lente glucocorticoid on the primary nephrotic syndrome (PNS) children's remission induction.Methods 54 PNS kid patients at the time of their initial treatment in Tianjin Children' s Hospital were randomly divided into three groups:prednisone group, triamcinolone group and methylprednisolone group; they were given corresponding GC treatment.Monitor 24-hour urinary protein (Upro) levels,Alb and Tcho.Record the Upro negative conversion time.Test the mRNA expression levels of the glucocorticoid receptor (GR) subtypes in PBMCs by semi-quantitative RT-PCR.Results Methylprednisolone was better than triamcinolone and prednisone on the 24 h Upro decrease and the increase of plasma Alb.Methylprednisolone and triamcinolone had a shorter Upro negative conversion time than prednisone group.The GR α up-regulation degree of methylprednisolone was better than triamcinolone and prednisone.Methylprednisolone and triamcinolone' s down-regulation ability of GR β was superior to prednisone.Conclusion After the GC treatment, the Upro negative conversion time, changes of Upro and Alb and the level of GR can be used as valuable indicators for efficacy assessment at remission induction period.The effects of methylprednisolone or triamcinolone are better than prednisone at the remission induction period of PNS in initial treatment.关键词
甲泼尼龙/曲安西龙/泼尼松/原发性肾病综合征/糖皮质激素受体分类
医药卫生引用本文复制引用
张碧丽,李琛,林书祥,王文红,李莉,张瑄
,范树颖,杜悦新..不同中效糖皮质激素诱导缓解儿童肾病综合征的疗效观察[J].中国实用儿科杂志,2011,26(2):118-120,3.
