中国实用儿科杂志2011，Vol.26Issue(2)：112-114,3.
丹参酮ⅡA对川崎病患儿炎性细胞因子及GMP-140影响的研究
Effects of TanshinoneⅡA on inflammatory cytokines and GMP-140 in the patients with Kawasaki disease
张庆 1李晓静 2于洁 1徐鸣 2周敏 2史宏 2黄成 2王雪梅2
作者信息
- 1. 重庆医科大学附属儿童医院,重庆,400014
- 2. 成都市儿童医院,成都,610017
- 折叠
摘要
Abstract
Objective To study the levels of serum IL-6, IL-8, IL-1 β , TNF- α, GMP-140and the number of platelet in different treatment for patients with Kawasaki disease, and to investigate the mechanism of TanshinoneⅡA in Kawasaki disease. Methods Sixty-one patients with Kawasaki disease and nineteen healthy children as controls were recruited into the study. The patients with Kawasaki disease were randomly divided into two groups: TanⅡA treatment group and contrast treatment group. The serum IL-6, IL-8, IL-1 β , TNF-α and GMP-140 levels were detected by ELISE and peripheral blood platelet number was measured using automatic hematocyte analyzer. Results The levels of serum IL-6, IL-8, IL-1 β , TNF-α and GMP-140 were increased before treatment, and decreased after treatment of five to seven days.The difference was statistically significant.The number of platelet was slightly increased before treatment, and significantly increased after treatment of five to seven days. After treatment of five to seven days, the levels of serum IL-6, IL-1 β and GMP-140 in the group of TanⅡA treatment decreased significantly compared with those in the group of contrast treatment, and the difference was statistically significant. Concluson TanⅡA might diminish the damage of immune vasculitis and platelet activation by decreasing the levels of serum IL-6, IL-1 β and GMP-140.关键词
川崎病/炎性细胞因子/GMP-140/血小板/丹参酮ⅡA分类
医药卫生引用本文复制引用
张庆,李晓静,于洁,徐鸣,周敏,史宏,黄成,王雪梅..丹参酮ⅡA对川崎病患儿炎性细胞因子及GMP-140影响的研究[J].中国实用儿科杂志,2011,26(2):112-114,3.
