中国医学科学院学报2011，Vol.33Issue(1)：5-8,4.DOI:10.3881/j.issn.1000-503X.2011.01.002
青少年库欣综合征患者的生长发育观察
Growth and Development of Adolescent Patients with Cushing's Syndrome
陈适 1卢琳 1潘慧 1朱慧娟 1童安莉 1陆召麟1
作者信息
- 1. 中国医学科学院北京协和医学院北京协和医院内分泌科卫生部内分泌重点实验室,北京,100730
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摘要
Abstract
Objective To elucidate the growth and development of patients with Cushing's syndrome (CS) in adolescence.Methods We analyzed the clinical data of 19 patients aged under 18 with CS.We divided the patients into two groups according to the height at diagnosis.The patients under the 3rd percentile were in the short stature group ( n = 12), and the others in the non-short stature group ( n = 7 ).The intergroup differences in disease course, age of onset, and 24-hour urinary free eortisol were analyzed.Results The median age at diagnosis was 13 years.The median disease course was 0.9 years.All those patients presented with typical clinical characteristics of CS.Twelve eases (63.2％) were in short stature group.The disease course of the short stature group was found significantly longer than that of the non-short stature group [(2.7 ± 1.7) years vs.(0.8 ± 0.6) years, P =0.013], but no significant difference was found in the age of onset (P =0.530) or 24-hour urinary free eortisol ( P =0.919 ) between the two groups.Conclusions The data suggest that short stature is common in adolescent CS patients.The growth delay may be correlated to the disease course of CS.关键词
库欣综合征/青少年/身高分类
医药卫生引用本文复制引用
陈适,卢琳,潘慧,朱慧娟,童安莉,陆召麟..青少年库欣综合征患者的生长发育观察[J].中国医学科学院学报,2011,33(1):5-8,4.
