中国中西医结合影像学杂志2011，Vol.9Issue(1)：4-8,5.DOI:10.3969/j.issn.1672-0512.2011.01.002
扩散和灌注加权成像对兔脑缺血半暗带的量化
Diffusion and perfusion weighted imaging in quantization of ischemic penumbra in brain of rabbits
摘要
Abstract
Objective : To discuss the value of diffusion weighted imaging (DWI) and perfusion weighted imaging (PWI) in the evaluation of ischemic penumbra (IP) salvaged.Methods : Fifty-eight successful models of middle cerebral artery occlusion (MCAO) with rahbits were randomly divided into permanent ischemic group (A group) and ischemic reperf'usion group (B group ).The A group was further divided into ischemic 1h , 3h , 6h , 12h , 24h , 48h groups (A1-6 group ).The B group was further divided into reperfusion Oh , 2h, 5h, 11h , 23h , 47h groups (B1-6 group ) after ischemic 1h.Then every group was examined with modalities including DWI and PWI.Results : The area of the abno rmal signal intensity on DWI in ischemic reperfusion group was significantly smaller than that in permanent ischemic group at the same time ; at ischemic 24h , the area of infarction got smoothly.At ischemic 1h, if the ADC , rCBV , rMTT ratio of region of interest changed respectively during (73.40±4.33 )％ ,(46.83±9.89 )％ and 1.58±0.04 , it might be IP , but if the ADC , rCBV ratio of region of' interest changed below respectively (58.83±6.06 )％ ,(22.87±8.19 )％ , and the rMTT ratio of region of interest was higher than 1.94±0.11 , it would become mreverdible necrosis.Conclusion : Comhined DWI with PWI could evaluate IP quickly and efficiently .关键词
缺血半暗带/磁共振成像,弥散/灌注加权成像/脑缺血/再灌注分类
医药卫生引用本文复制引用
姜传武,刘学军,刘珍友,李文华,隋庆兰,徐文坚,许波..扩散和灌注加权成像对兔脑缺血半暗带的量化[J].中国中西医结合影像学杂志,2011,9(1):4-8,5.基金项目
山东省卫生厅和青岛市科技局基金资助项目(编号:04-2-NY-46). （编号:04-2-NY-46）
